Prevalence and clinical significance of sterile intra-amniotic inflammation in patients with preterm labor and intact membranes. Romero R, Miranda J, Chaiworapongsa T, et al. The fetus grows inside an amniotic sac filled with amniotic fluid during pregnancy. What is amniotic fluid Amniotic fluid is a water-like substance surrounding the fetus in your uterus. Cervical length and obstetric history predict spontaneous preterm birth: development and validation of a model to provide individualized risk assessment. Overview Amniotic fluid is a water-like substance that surrounds and protects a fetus during pregnancy. 2014 9(10):e109069.Ĭelik E, To M, Gajewska K, Smith GCS, Nicolaides KH, Fetal Medicine Foundation Second Trimester Screening Group. Brazilian multicentre study on preterm birth (EMIP): prevalence and factors associated with spontaneous preterm birth.

National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. © 2019 Nordic Federation of Societies of Obstetrics and Gynecology.īlencowe H, Cousens S, Oestergaard MZ, et al. This study suggests that antibiotic treatment in high-risk pregnant women with amniotic fluid 'sludge' can be effective in the reduction of the frequency of spontaneous preterm delivery and can increase the birthweight.Īmniotic fluid “sludge” cervical length chorioamnionitis preterm birth short cervix. 2554 ± 819 g, respectively P = 0.028), with no statistical significance for others variables. Birthweight was significantly different between the study groups (2961 ± 705 vs. The effect of antimicrobials was also compared in the subgroup of women at high risk for spontaneous preterm birth (ie, cervical length ≤25 mm, history of spontaneous preterm birth, previous spontaneous loss in the second trimester, Mullerian malformations or cervical conization).Īntibiotic therapy reduced the incidence of spontaneous preterm birth at <34 weeks (13.2% vs 38.5%, P = 0.047) in women at high-risk for preterm birth, with an odds ratio of 0.24 (95% confidence interval 0.06-0.99). The groups were compared considering the incidence of spontaneous preterm delivery. Women admitted from October 2010 to September 2012 received no treatment with antibiotics, whereas those admitted from October 2012 to January 2015, received routinely clindamycin and first-generation cephalosporin. The objective of this study was to evaluate routine antibiotic treatment in the presence of amniotic fluid 'sludge' for prevention of preterm delivery.Ī historically controlled observational study was performed between October 2010 and January 2015, including a total of 86 pregnant women with singleton pregnancies and the presence of amniotic fluid 'sludge' at ultrasound. Only one study evaluating the use of antibiotics in the presence of amniotic fluid 'sludge' showed reduced rates of spontaneous preterm birth at <34 weeks. Amniotic fluid 'sludge' has been associated with an increased rate of spontaneous preterm delivery before 35 weeks, a higher frequency of clinical and histologic chorioamnionitis in a high-risk population.

Treatment for leaking amniotic fluid